Figure 2: Altered serum cytokines and serum lipids in mice. (a) Leptin levels were elevated in (versus KK-a/a control). Addition of uninephrectomy (Unx) elevated serum leptin, both in KK-a/a and in mice (). (b) A similar profile was observed for serum triglycerides, which were elevated in (versus KK-a/a control). As with leptin, Unx further elevated triglycerides both in KK-a/a and in mice (). (c) Relative to KK-a/a controls, KK-a/a + Unx, , and + Unx mice all showed markedly elevated serum cholesterol (). (d) Serum PAI-1 levels were elevated in mice compared to age-matched KK-a/a animals (). However, PAI-1 levels in were unaffected by Unx.