498925.fig.002a
(a)
498925.fig.002b
(b)
498925.fig.002c
(c)
498925.fig.002d
(d)
Figure 2: Altered serum cytokines and serum lipids in mice. (a) Leptin levels were elevated in (versus KK-a/a control). Addition of uninephrectomy (Unx) elevated serum leptin, both in KK-a/a and in mice ( ). (b) A similar profile was observed for serum triglycerides, which were elevated in (versus KK-a/a control). As with leptin, Unx further elevated triglycerides both in KK-a/a and in mice ( ). (c) Relative to KK-a/a controls, KK-a/a + Unx, , and + Unx mice all showed markedly elevated serum cholesterol ( ). (d) Serum PAI-1 levels were elevated in mice compared to age-matched KK-a/a animals ( ). However, PAI-1 levels in were unaffected by Unx.