Glomerulopathy in the KK.Cg-A^y/J Mouse Reflects the Pathology of Diabetic Nephropathy

Figure 4

Decreased renal function in KK-𝐴^𝑦 is exacerbated by uninephrectomy. (a) Compared to KK-a/a mice, blood urea nitrogen (BUN) is slightly elevated in KK-𝐴^𝑦 and KK-a/a + Unx, though this difference is not statistically significant at later time points in the KK-a/a + Unx group. Uninephrectomy further elevates BUN in KK-𝐴^𝑦, with BUN increased by twofold, indicating mild uremia in KK-𝐴^𝑦 + Unx animals. (b) Renal function, as measured by glomerular filtration rate (GFR), is reduced by 32% in KK-𝐴^𝑦 + Unx mice compared to KK-a/a littermate controls (𝑃<0.001).

(a)

(b)