IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers

Table 3

Summary of IGF-1 values.

IGF-1	Minimum	Maximum	Mean ± SD
Initial values
Overall	48	377	152.36 ± 66.93
Healed	48	377	155.73 ± 70.00
Non-healed	85	233	135.50 ± 48.82
IGF-1 final values
Overall	57	480	201.12 ± 92.69
Healed	57	480	216.91 ± 92.12
Non-healed	80	180	122.16 ± 43.07
IGF-1 response to HBOT
Overall	−55	+276	48.75 ± 62.10
Healed	−25	+276	61.17 ± 59.84
Non-healed	−55	+25	−13.33 ± 25.67
IGF-1 percentage (final/initial)
Overall	0.68	2.90	1.37 ± 0.49
Healed	0.86	2.90	1.46 ± 0.49
Non-healed	0.68	1.29	0.91 ± 0.19
Statistics
Parameter		Healed/nonhealed
IGF-1 initial		𝑃=0.399
IGF-1 response to HBOT		𝑃<0.001
IGF-1 percentage (final value/initial value)		𝑃<0.001
IGF-1 response to HBOT and IGF-1 percentage (final/initial)
Age		𝑃=0.93
Duration of DM		𝑃=0.46
Wagner grade		𝑃=0.76
HbA1C initial		𝑃=0.88
HbA1C final		𝑃=0.70
HbA1C response to HBOT and percentage		𝑃=0.40 and 0.37, respectively