Deoxycholic Acid as a Modifier of the Permeation of Gliclazide through the Blood Brain Barrier of a Rat

Table 2

Penetration coefficient of gliclazide in the brain tissue after intra-arterial application of gliclazide (𝐾_𝑏/𝑝).

Groups		Group 1: healthy; Gliclazide; 𝑛=6	Group 2: healthy; Gliclazide + DA; 𝑛=6	Group 3: diabetic Gliclazide; 𝑛=6	Group 4: diabetic; Gliclazide + DA; 𝑛=6
𝐾𝑏/𝑝—mean ± SD	BS	0.09±0.06	1.35±0.92^∗	2.13±1.41^#	6.15±4.74^××,×
	C	0.13±0.06	6.23±3.95^∗	4.40±2.93^#	14.05±8.53^××
	LCH	0.09±0.04	0.11±0.07	0.09±0.04	1.10±0.8^××,×
	RCH	0.15±0.06	0.46±0.38^∗	0.32±0.23	1.23±0.98^××,×
	B	0.12±0.06	1.33±1.01^∗	1.66±0.93^#	4.09±2.87^××,×

LCH: left cerebral hemisphere; RCH: right cerebral hemisphere; BS: brain stem; C: cerebellum, B: total brain.
*Group 2 versus Group 1, 𝑃≤0.05; ^#Group 3 versus Group 1, 𝑃≤0.05; ^×Group 4 versus Group 3, 𝑃≤0.05; ^##Group 4 versus Group 2, 𝑃≤0.05; ^××Group 4 versus Group 1, 𝑃≤0.05.