Deoxycholic Acid as a Modifier of the Permeation of Gliclazide through the Blood Brain Barrier of a Rat

Table 3

Gliclazide serum concentrations (𝜇g/mL) 30, 60, 150, and 240 seconds after intra-arterial injection.

Groups	Time (s)	Group 1: healthy; Gliclazide; 𝑛=6	Group 2: healthy Gliclazide + DA; 𝑛=6	Group 3: diabetic; Gliclazide; 𝑛=6	Group 4: diabetic Gliclazide + DA; 𝑛=6
Gliclazide serum concentrations; (𝜇g/mL): mean ± SD	30	15.13±4.79	22.77±7.50	12.85±5	9.44±5.72
	60	23.28±4.75	15.37±5.20	10.65±3.61	8.29±4.92
	150	13.94±3.44	10.98±3.75	9.16±4.77	7.22±2.94
	240	15.99±4.26	9.79±3.14^∗	11.12±4.56^#	7.43±3.92^××

∗Group 2 versus Group 1, 𝑃≤0.05; ^××Group 4 versus Group 1, 𝑃≤0.05; ^#Group 3 versus Group 1, 𝑃≤0.05.