Research Article
Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes
Table 4
Summary of responses of diabetic subjects to Tregitopes in vitro. Effects of Tregitopes on ELISpot responses to the panel GAD65 epitopes, as reported in detail in Table 3, are summarized here. In the two-step T cell assays, IFN ELISpot responses to GAD65 peptides were suppressed for 78% of the peptides tested using diabetic subject PBMC and for 74% of the peptides tested using normal control subjects. The suppression reached statistical significance for more than a quarter (26%) of all assays performed.
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