Antioxidant N-Acetylcysteine Attenuates the Reduction of Brg1 Protein Expression in the Myocardium of Type 1 Diabetic Rats

Table 3

M-mode Echocardiographic and transmitral Doppler flow velocity indices of LV dimensions and functions.

	C	D	NAC
LVIDd (mm)	8.30±0.17	7.90±0.15	7.75±0.15^∗
LVIDs (mm)	4.80±0.14	4.55±0.13	4.65±0.25
IVSs (mm)	2.25±0.11	2.24±0.08	2.08±0.06
IVSd (mm)	1.72±0.06	1.78±0.05	1.60±0.05
LVPWs (mm)	3.06±0.07	2.92±0.05	2.57±0.05^∗
LVPWd (mm)	1.92±0.04	1.87±0.05	1.62±0.03^#
LVM (mg)	964±27.5	812±14.3^∗	707±18.7^∗
LVM/body	1.90±0.04	2.44±0.07^∗	2.17±0.04^#
weight (mg/g)
HR (bpm)	323±7.8	285±10.8^∗	286±9.2^∗
LVVd (μL)	372.7±23.4	318.5±24.2^∗	319.7±18.4
LVVs (μL)	107.8±10.6	93.7±9.8	101.5±13.2
IVRT  (ms)	21.6±1.6	32.5±1.8^∗	28.5±1.4^∗
MV E (cm/s)	133.2±58.3	1217±30.2	1181.7±62.2
MV A (cm/s)	909.5±36.2	1028.9±36.1	838.6±63.8^#
E/A	1.49±0.09	1.19±0.03^∗	1.45±0.07^#
SV (μL)	277.8±17.8	226.7±17.4^∗	218.3±12.2^∗
FS (%)	42.5±0.9	42.1±0.8	40.7±1.0
EF (%)	71.6±1.7	72.2±1.7	68.8±3.0

All values are expressed as Mean ± S.E.M. 𝑛=6 per group. M-mode Echocardiographic and transmitral Doppler flow velocity indices of LV dimensions and functions in Control (C), Diabeties (D), Ruboxistaurin (RBX), N-acetylcysteine (NAC) rats. ^∗𝑃<0.05 or 0.01 versus C; ^#𝑃<0.05 or 0.01 versus D. LVIDd: LV internal diastolic diameter; LVIDs: LV internal systolic diameter; IVSs: systolic interventricularseptal thickness; IVSd: diastolic interventricularseptal thickness; LVPWs: LV systolic posterior wall thickness; LVPWd: LV diastolic posterior wall thickness; LVM: LV mass; HR: heart rate; LVVd: LV end-diastolic volume; LVVs: LV end-systolic volume; IVRT: isovolumetric relaxation time; SV: stroke volume; FS: fractional shortening; EF: ejection fraction.