The Missing Heritability in T1D and Potential New Targets for Prevention

Figure 2

Nonsynonymous amino acid sequence alignments of beta chain CDR1 and CDR2 regions of Vβ13a, found in T1D susceptible (T1D-S) rats, and Vβ13b, which is found in T1D resistant (T1D-R) rats [17, 20]. Both the CDR1 and CDR2 regions (red) exhibit differences (all indicated in yellow). Vβ13a is encoded by Tcrb-V13S1A1 and has been found in the BBDR, BBDP, LEW.1WR1, LEW.1AR1-iddm, KDP, and PVGRT1u strains, all of which are T1D susceptible; Vβ13b is encoded by Tcrb-V13S1A2 and is found in T1D resistant WF and BN rats [17]. Another allele, Tcrb-V13S1A3P, is a pseudogene found in the resistant F344 rat [17, 20].