The Missing Heritability in T1D and Potential New Targets for Prevention

Table 1

Type 1 diabetes frequency in rats as a function of MHC and TCR genotypes.

TCR	MHC	Diabetes	Strains
Vβ13a present	RT1B/Du	High susceptibility to diabetes	BBDP and BBDR
			LEW.1WR1 and LEW.1AR1-iddm
			KDP
			PVG.RT1u
Vβ13a absent	RT1B/Du	Low penetrance of T1D	WF
Vβ13a present	Non-RT1B/Du	No T1D	Many

Coassociation of Class II MHC haplotype and TCR usage in T1D in rats [17–19].