Review Article

Porcine Models of Accelerated Coronary Atherosclerosis: Role of Diabetes Mellitus and Hypercholesterolemia

Figure 1

Examples of atherosclerotic lesions from DM/HC pigs. (a) Low power magnification of a coronary artery with a severe atherosclerotic lesion, obtained 6 months after DM/HC induction. Artery stained with Cathepsin S (brown cells) to denote the presence of inflammatory cells showing protease activity. Lumen is within the outlined box, *—calcification and NC-necrotic core. (b) High power view of outlined area in (a) with L denoting the arterial lumen. Cathepsin positive areas near the lumen indicate a thinned fibrous cap with increased inflammation. (c) Movat’s staining of a high-risk coronary fibroatheroma showing two large necrotic cores covered by a fibrous cap. (d) Longitudinal view of the abdominal aorta demonstrating severe, diffuse atherosclerosis between the renal arteries (R) and the distal bifurcation (*) into the iliac arteries (I). The ostia of the iliac arteries are generally severely diseased in this model.
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