Journal of Diabetes Research

Research Article

The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy

Table 2

Metabolic effects of STZ-induced diabetes and treatments in rats.
Parameters Body weight (g)Food intake (g) Water intake (mL) Urine output (mL) Blood glucose
(mmol/L)
0 w     
 Control 443.33 ± 39.28*24.92 ± 8.59*40.0 ± 28.5**10.80 ± 5.45**4.48 ± 0.15**
 STZ 303.29 ± 46.61 56.21 ± 5.25 300.03 ± 56.91 197.43 ± 42.55 28.07 ± 8.91
4 w     
 Control 455.20 ± 29.54*25.30 ± 4.6*40.00 ± 12.51**10.80 ± 5.45**4.28 ± 0.35**
 STZ + vehicle (n=7)303.29 ± 46.61 56.21 ± 5.25 300.00 ± 56.92 217.43 ± 42.55 28.07 ± 8.91
 STZ + DP 309.37 ± 44.57 50.28 ± 8.44 227.86 ± 38.06 171.43 ± 23.87 28.28 ± 7.18
 STZ + irbesartan 346.83 ± 39.28 52.25 ± 9.80 253.43 ± 44.40 184.14 ± 34.51 24.97 ± 1.03
8 w
     
 Control 521.71 ± 42.59*23.14 ± 5.81*30.00 ± 11.00**14.93 ± 2.46**4.13 ± 0.41**
 STZ + vehicle 331.88 ± 71.39 50.81 ± 8.27 227.50 ± 41.75 156.50 ± 20.74 28.88 ± 8.32
 STZ + DP 296.29 ± 25.12 59.01 ± 7.36 232.33 ± 33.69 171.00 ± 25.82 28.33 ± 6.53
 STZ + irbesartan 311.00 ± 51.78 52.25 ± 8.08 241.25 ± 54.36 178.75 ± 44.52 25.70 ± 1.28
12 w
     
 Control 582.33 ± 85.35*22.33 ± 5.05*40.00 ± 10.95**12.35 ± 4.73**4.16 ± 0.54**
 STZ + vehicle 328.22 ± 55.96 51.77 ± 8.60 214.44 ± 44.82 160.33 ± 38.63 28.06 ± 4.87
 STZ + DP 326.38 ± 54.35 53.56 ± 7.36 246.25 ± 38.89 199.38 ± 34.12 28.28 ± 1.77
 STZ + irbesartan 353.00 ± 43.17 46.35 ± 4.58 232.86 ± 25.63 189.29 ± 38.90 27.20 ± 1.91
versus STZ + vehicle rats ** versus STZ + vehicle rats.