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Journal of Diabetes Research
Volume 2013 (2013), Article ID 849295, 9 pages
http://dx.doi.org/10.1155/2013/849295
Clinical Study

Effects of Glucose Load and Nateglinide Intervention on Endothelial Function and Oxidative Stress

1VIP Department, Beijing Hospital of the Ministry of Health, Dongdan Dahua, Road Number One, Beijing 100730, China
2Endocrinology and Metabolism Department, Beijing Hospital of the Ministry of Health, Dongdan Dahua, Road Number One, Beijing 100730, China
3Ultrasound Division, Beijing Hospital of the Ministry of Health, Dongdan Dahua, Road Number One, Beijing 100730, China
4Laboratory Division, Beijing Hospital of the Ministry of Health, Dongdan Dahua, Road Number One, Beijing 100730, China

Received 14 November 2012; Revised 17 February 2013; Accepted 18 February 2013

Academic Editor: Weiping Jia

Copyright © 2013 Leilei Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We analysed endothelial function and oxidative stress in patients with abnormal glucose metabolism, the effect of glucose load, and the impact of nateglinide. 109 participants were grouped into newly diagnosed diabetes, prediabetes, and control. Fasting plasma glucose (FPG), postprandial plasma glucose (PPG), glycosylated haemoglobin ( ), and glycated albumin (GA) varied significantly among the study groups ( ). Nitric oxide (NO) and insulin resistance index (HOMA-IRI) levels were markedly different between the newly diagnosed diabetes and the control ( ). Glucose loading lowered flow-mediated endothelium-dependent dilation (FMEDD), NO, and superoxide dismutase (SOD) ( ). Fasting and glucose loading FMEDD, FPG, PPG, , and GA were negatively correlated ( , −0.4602, −0.3895, −0.3897, and , −0.4803, −0.4494, −0.3885; ), whereas NO, SOD, and HOMA-β were positively correlated ( , 0.3211, 0.311, and , 0.361, 0.2569; ). After the treatment with nateglinide, significant decreases in FPG, PPG, GA, HbA1C, endothelin-1(ET-1), malondialdehyde (MDA), and HOMA-IRI were observed, whereas FMEDD, NO, and SOD increased ( ). Thus, the study demonstrated the adverse effect of glucose load on endothelial function and oxidative stress. Nateglinide lowers blood glucose, reduces insulin resistance and oxidative stress, and improves endothelial function in newly diagnosed diabetes.