940710.fig.004a
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940710.fig.004b
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Figure 4: Foxp3+ Treg cell ablation in NOD.Foxp3DTR-GFP mice. (a) Percentage of Foxp3DTR-GFP+ cells among CD4+ T cells in subcutaneous lymph nodes (scLN, top) and pancreatic LNs (pLN, bottom) of NOD.Foxp3DTR-GFP  × BDC2.5 mice, which were either left untreated (dashed line) or i.p. injected with DT (0.5  g/mouse on 3 consecutive days). Symbols represent individual mice at indicated time points after the first DT administration. (b) Blood glucose concentrations and (c) diabetes incidence of NOD.Foxp mice (blue triangles: females, ; blue circles: males, ) and NOD.Foxp ×BDC2.5 mice (red triangles: females, ; red circles: males, ), after DT administration, as indicated by the arrowheads.