Variations in Rodent Models of Type 1 Diabetes: Islet Morphology

Figure 7

Blood glucose levels of STZ-treated DA rats. Diabetes was induced in DA rats by a STZ injection while 3 control animals were injected with vehicle. Blood glucose levels increased rapidly in the STZ-treated rats, both diabetic normoglycemic (DN) and diabetic hyperglycemic (DH). In the insulin treated rats (DN group), the blood glucose returned to normal values by day 12 (diamond symbol) following the insulin pellet implantation. Blood glucose levels of control animals were constant at approximately 110 mg/dL.