The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications

<table>Histopathological observations in kidney of SDT rats. Histological and immunohistological analysis of glomeruli in SD rats (a–c) and SDT rats (d–f). In the glomeruli of SDT rats, basement membrane thickening and mesangial matrix proliferation were observed at 50 weeks of age (bar <svg height="6.4625001" id="M8" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.1 6.4625001" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> 20 <i>μ</i>m). Nodular lesions were found in a few glomeruli from 68-week-old SDT rats (g) (PAS stain, bar <svg height="6.4625001" id="M9" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.1 6.4625001" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,6.4)"><path d="M535 323h-483v50h483v-50zM535 138h-483v50h483v-50z" id="x3D"></path></g>
</svg> 20 <i>μ</i>m). In the renal tubules of SDT rats, dilation (arrowhead) and glycogen deposition in the epithelium (*) were observed (h) (HE stain, bar <svg height="6.4625001" id="M10" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.1 6.4625001" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,6.4)"><path d="M535 323h-483v50h483v-50zM535 138h-483v50h483v-50z" id="x3D"></path></g>
</svg> 50 <i>μ</i>m). Figures are modified from [<a href="/journals/jdr/2013/976209/#B41">41</a>].</table>

Journal of Diabetes Research

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Figure 6

Figure 6: The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications 