The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications

<table>Diabetic peripheral neuropathy and histopathology in sural nerves of SDT rats. Serial changes of tibial motor nerve conduction velocity (MNCV) in male SD rats (white square) and male SDT rats (green square) (a). MNCV reduced after the onset of diabetes. Data represent means ± SD (<svg height="11.375" id="M11" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 42.5625 11.375" width="42.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> (versus age-matched SD rats, unpaired <i>t</i>-test). Morphologically, SDT rats revealed significant atrophy in myelinated nerve at 48 weeks of age. Occluded/thickened epineurial arterioles were found in SDT rats. Typical low (b, d) and high (c, e) magnification of microphotographs of sural nerves from SD rat and SDT rat (toluidine blue stain). Figures are modified from [<a href="/journals/jdr/2013/976209/#B45">45</a>].</table>

Journal of Diabetes Research

fig7

Figure 7

Figure 7: The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications 