The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications

<table>Bone properties of SDT rats. Bone mineral density (BMD) of the whole tibia (a) and mechanical property of the femur midshaft (b) are clearly indicating diabetes-induced osteoporosis in SDT rats. White column: male SD rats, green column: male SDT rats (40 weeks of age). Data represent means ± SD (<svg height="11.375" id="M13" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 42.5625 11.375" width="42.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> (versus SD rats, unpaired <i>t</i>-test). The reconstructed bone microstructure 3D images of femur from 40 weeks SDT rats show the obvious bone loss (c) (bar <svg height="6.4625001" id="M16" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.1 6.4625001" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> 2 mm). Figures are modified from [<a href="/journals/jdr/2013/976209/#B51">50</a>].</table>

Journal of Diabetes Research

fig8

Figure 8

Figure 8: The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications 