Notch Signaling Molecules Activate TGF-<i>β</i> in Rat Mesangial Cells under High Glucose Conditions

<table>The expression of Notch pathway components after intervention with DAPT determined using PCR for 12 h. (a) RT-PCR strip chart for Notch1 and Jagged1. (b) RT-PCR strip chart for Hes1. (c) The gray graph shows the relative statistical values for Notch pathway components in each group. Compared with the NC group, the expression of the Notch pathway components mRNA was significantly increased in the HG2 group. After DAPT intervention, the mRNA expression of Notch pathway components decreased. <sup>▴</sup><svg height="11.375" id="M46" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus NC group; <sup>•</sup><svg height="11.375" id="M47" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus HG2 group.</table>

Journal of Diabetes Research

fig6

Figure 6

Figure 6: Notch Signaling Molecules Activate TGF-<i>β</i> in Rat Mesangial Cells under High Glucose Conditions 

Journal of Diabetes Research

Notch Signaling Molecules Activate TGF-β in Rat Mesangial Cells under High Glucose Conditions

Figure 6