T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status and Other Main Causes of End-Stage Renal Disease
Table 7
Comparison of the distribution of polymorphic variants of tested genes between ESRD patients treated with hemodialysis due to type 2 DM nephropathy grouped by diagnosis of CAD.
Parameter
Type 2 DM nephropathy with CAD (frequency)
Type 2 DM nephropathy without CAD (frequency)
Odds ratio (95% CI)
Two-tailed
IL18 rs360719
= 124
= 109
TT
68 (0.55)
53 (0.49)
Referent
0.269
CT
51 (0.41)
49 (0.45)
1.128 (0.725–1.754)
0.653
CC
5 (0.04)
7 (0.06)
0.628 (0.194–2.036)
0.557
CT + CC
56 (0.45)
56 (0.51)
0.879 (0.560–1.380)
0.645
MAF
61 (0.25)
63 (0.29)
0.803 (0.532–1.211)
0.345
IL12A rs568408
= 117
= 102
GG
83 (0.71)
77 (0.63)
Referent
0.361
AG
28 (0.24)
22 (0.22)
1.181 (0.623–2.236)
0.630
AA
6 (0.05)
3 (0.03)
1.855 (0.448–7.678)
0.502
AG + AA
34 (0.29)
25 (0.25)
1.262 (0.691–2.304)
0.542
MAF
40 (0.17)
28 (0.14)
1.311 (0.776–2.214)
0.378
IL12B rs3212227
= 124
= 109
AA
78 (0.63)
69 (0.63)
Referent
0.906
AC
43 (0.35)
36 (0.33)
1.057 (0.611–1.829)
0.889
CC
3 (0.02)
4 (0.04)
0.664 (0.143–3.069)
0.708
AC + CC
46 (0.37)
40 (0.37)
1.017 (0.597–1.734)
1.000
MAF
49 (0.20)
44 (0.20)
0.974 (0.618–1.535)
0.909
IL4R rs1805015
= 144
= 127
TT
95 (0.66)
86 (0.68)
Referent
0.947
CT
42 (0.29)
32 (0.25)
1.188 (0.689–2.048)
0.581
CC
7 (0.05)
9 (0.07)
0.704 (0.251–1.972)
0.605
CT + CC
49 (0.34)
41 (0.32)
1.082 (0.652–1.797)
0.797
MAF
56 (0.19)
50 (0.20)
0.985 (0.644–1.504)
0.944
IL13 rs20541
= 144
= 127
CC
80 (0.56)
71 (0.56)
Referent
0.867
CT
55 (0.38)
46 (0.36)
1.061 (0.640–1.759)
0.898
TT
9 (0.06)
10 (0.08)
0.799 (0.307–2.077)
0.808
CT + TT
64 (0.44)
56 (0.44)
1.014 (0.627–1.640)
1.000
MAF
73 (0.25)
92 (0.26)
0.967 (0.657–1.423)
0.944
IL28B rs8099917
= 163
= 145
TT
105 (0.64)
97 (0.67)
Referent
0.752
GT
52 (0.32)
42 (0.29)
1.144 (0.700–1.870)
0.618
GG
6 (0.04)
6 (0.04)
0.924 (0.288–2.961)
1.000
GT + GG
58 (0.36)
48 (0.33)
1.116 (0.697–1.189)
0.719
MAF
64 (0.20)
54 (0.19)
1.068 (0.714–1.597)
0.829
IL28B rs12979860
= 163
= 142
CC
69 (0.42)
66 (0.46)
Referent
0.352
CT
73 (0.45)
62 (0.44)
1.126 (0.698–1.816)
0.715
TT
21 (0.13)
14 (0.10)
1.435 (0.674–3.055)
0.448
CT + TT
94 (0.58)
76 (0.54)
1.183 (0.752–1.861)
0.490
MAF
115 (0.35)
90 (0.32)
1.175 (0.838–1.647)
0.396
GC rs2298849
= 172
= 158a
TT
99 (0.58)
106 (0.67)
Referent
0.173
CT
60 (0.35)
40 (0.25)
1.606 (0.989–2.608)
0.067
CC
13 (0.07)
12 (0.08)
1.160 (0.505–2.663)
0.833
CT + CC
73 (0.42)
52 (0.33)
1.503 (0.959–2.355)
0.088
MAF
166 (0.25)
64 (0.20)
1.313 (0.909–1.895)
0.174
GC rs7041
= 161
= 151
GG
57 (0.35)
46 (0.30)
Referent
0.844
GT
69 (0.43)
82 (0.54)
1.327 (0.825–2.134)
0.277
TT
35 (0.22)
23 (0.15)
1.629 (0.900–2.949)
0.136
GT + TT
104 (0.65)
105 (0.70)
1.061 (0.721–1.559)
0.769
MAF
139 (0.43)
128 (0.42)
1.025 (0.746–1.409)
0.943
GC rs1155563
= 172
= 157
TT
82 (0.48)
79 (0.50)
Referent
0.645
CT
70 (0.41)
61 (0.39)
1.106 (0.697–1.755)
0.724
CC
20 (0.12)
17 (0.11)
1.133 (0.554–2.321)
0.856
CT + CC
90 (0.52)
78 (0.50)
1.112 (0.721–1.714)
0.660
MAF
110 (0.32)
95 (0.30)
1.084 (0.779–1.508)
0.695
VDR rs2228570
= 162
= 152
CC
43 (0.27)
44 (0.29)
Referent
0.316
CT
93 (0.57)
68 (0.45)
1.400 (0.829–2.363)
0.230
TT
26 (0.16)
40 (0.26)
0.665 (0.348–1.272)
0.252
CT + TT
119 (0.73)
108 (0.71)
1.128 (0.688–1.849)
0.705
MAF
145 (0.45)
148 (0.49)
0.854 (0.624–1.169)
0.365
VDR rs1544410
= 170
= 155
GG
65 (0.38)
61 (0.39)
Referent
0.772
AG
79 (0.46)
72 (0.46)
1.030 (0.641–1.653)
0.905
AA
26 (0.15)
22 (0.14)
1.109 (0.569–2.160)
0.865
AG + AA
105 (0.62)
94 (0.61)
1.048 (0.671–1.639)
0.909
MAF
131 (0.39)
116 (0.37)
1.048 (0.763–1.440)
0.833
RXRA rs10776909
= 172
= 158
CC
112 (0.65)
104 (0.66)
Referent
0.621
CT
48 (0.28)
47 (0.30)
0.948 (0.585–1.537)
0.902
TT
12 (0.07)
7 (0.04)
1.592 (0.604–4.198)
0.473
CT + TT
60 (0.35)
54 (0.34)
1.032 (0.655–1.625)
0.908
MAF
72 (0.21)
61 (0.19)
1.107 (0.756–1.621)
0.672
RXRA rs10881578
= 173
= 158
AA
89 (0.51)
92 (0.58)
Referent
0.192
AG
65 (0.38)
53 (0.34)
1.268 (0.796–2.019)
0.345
GG
19 (0.11)
13 (0.08)
1.511 (0.704–3.241)
0.340
AG + GG
84 (0.49)
66 (0.42)
1.316 (0.852–2.032)
0.226
MAF
103 (0.30)
79 (0.25)
1.272 (0.902–1.793)
0.199
RXRA rs749759
= 169
= 153
GG
100 (0.59)
89 (0.58)
Referent
0.812
AG
59 (0.35)
54 (0.35)
0.972 (0.610–1.551)
1.000
AA
10 (0.06)
10 (0.07)
0.890 (0.354–2.238)
0.818
AG + AA
69 (0.41)
64 (0.42)
0.960 (0.615–1.496)
0.910
MAF
79 (0.23)
74 (0.24)
0.956 (0.665–1.375)
0.882
CAD: coronary artery disease, ESRD: end-stage renal disease, DM: diabetes mellitus, and MAF: minor allele frequency.
aNot consistent with Hardy-Weinberg equilibrium.
