T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status and Other Main Causes of End-Stage Renal Disease
Table 8
Comparison of the distribution of polymorphic variants of tested genes between type 2 DM nephropathy patients with diagnosis of CAD and healthy controls.
Parameter
Type 2 DM nephropathy with CAD (frequency)
Healthy controls (frequency)
Odds ratio (95% CI)
Two-tailed
IL18 rs360719
= 124
= 240
TT
68 (0.55)
121 (0.50)
Referent
0.186
CT
51 (0.41)
98 (0.41)
0.926 (0.590–1.453)
0.819
CC
5 (0.04)
21 (0.09)
0.424 (0.153–1.174)
0.122
CT + CC
56 (0.45)
119 (0.50)
0.837 (0.542–1.294)
0.440
MAF
61 (0.25)
140 (0.29)
0.792 (0.558–1.124)
0.223
IL12A rs568408
= 117
= 240
GG
83 (0.71)
171 (0.71)
Referent
0.626
AG
28 (0.24)
63 (0.26)
0.916 (0.546–1.535)
0.794
AA
6 (0.05)
6 (0.03)
2.060 (0.645–6.583)
0.348
AG + AA
34 (0.29)
69 (0.29)
1.015 (0.624–1.653)
1.000
MAF
40 (0.17)
75 (0.16)
1.113 (0.731–1.695)
0.695
IL12B rs3212227
= 124
= 240
AA
78 (0.63)
151 (0.63)
Referent
0.475
AC
43 (0.35)
77 (0.32)
1.081 (0.681–1.717)
0.813
CC
3 (0.02)
12 (0.05)
0.484 (0.133–1.766)
0.397
AC + CC
46 (0.37)
89 (0.37)
1.001 (0.639–1.567)
1.000
MAF
49 (0.20)
101 (0.21)
0.924 (0.631–1.354)
0.757
IL4R rs1805015
= 144
= 225
TT
95 (0.66)
162 (0.72)
Referent
0.285
CT
42 (0.29)
53 (0.24)
1.351 (0.838–2.179)
0.221
CC
7 (0.05)
10 (0.04)
1.194 (0.440–3.240)
0.798
CT + CC
49 (0.34)
63 (0.28)
1.326 (0.845–2.083)
0.246
MAF
56 (0.19)
73 (0.16)
1.247 (0.848–1.832)
0.305
IL13 rs20541
= 144
= 230
CC
80 (0.56)
124 (0.54)
Referent
0.469
CT
55 (0.38)
84 (0.36)
1.015 (0.653–1.578)
1.000
TT
9 (0.06)
22 (0.10)
0.634 (0.278–1.447)
0.324
CT + TT
64 (0.44)
106 (0.46)
0.936 (0.616–1.422)
0.831
MAF
73 (0.25)
128 (0.28)
0.881 (0.630–1.231)
0.510
IL28B rs8099917
= 163
= 375
TT
105 (0.64)
245 (0.65)
Referent
0.584
GT
52 (0.32)
123 (0.33)
0.986 (0.663–1.467)
1.000
GG
6 (0.04)
7 (0.02)
2.000 (0.656–6.094)
0.229
GT + GG
58 (0.36)
130 (0.35)
1.041 (0.709–1.530)
0.845
MAF
64 (0.20)
137 (0.18)
1.093 (0.786–1.521)
0.658
IL28B rs12979860
= 163
= 372
CC
69 (0.42)
164 (0.44)
Referent
0.281
CT
73 (0.45)
166 (0.45)
1.045 (0.705–1.549)
0.841
TT
21 (0.13)
42 (0.11)
1.188 (0.656–2.154)
0.644
CT + TT
94 (0.58)
208 (0.56)
1.074 (0.740–1.558)
0.776
MAF
115 (0.35)
250 (0.34)
1.077 (0.819–1.416)
0.644
GC rs2298849
= 172
= 375
TT
99 (0.58)
237 (0.63)
Referent
0.080
CT
60 (0.35)
124 (0.33)
1.158 (0.786–1.706)
0.486
CC
13 (0.07)
14 (0.04)
2.223 (1.008–4.901)
0.052
CT + CC
73 (0.42)
138 (0.37)
1.266 (0.876–1.830)
0.220
MAF
166 (0.25)
152 (0.20)
1.311 (0.969–1.774)
0.092
GC rs7041
= 161
= 361
GG
57 (0.35)
116 (0.32)
Referent
0.748
GT
69 (0.43)
186 (0.52)
0.755 (0.496–1.150)
0.196
TT
35 (0.22)
59 (0.16)
1.207 (0.714–2.040)
0.502
GT + TT
104 (0.65)
245 (0.68)
0.864 (0.584–1.278)
0.482
MAF
139 (0.43)
304 (0.42)
1.044 (0.801–1.362)
0.800
GC rs1155563
= 172
= 377
TT
82 (0.48)
189 (0.50)
Referent
0.378
CT
70 (0.41)
155 (0.41)
1.041 (0.710–1.527)
0.845
CC
20 (0.12)
33 (0.09)
1.397 (0.757–2.578)
0.332
CT + CC
90 (0.52)
188 (0.50)
1.103 (0.769–1.583)
0.646
MAF
110 (0.32)
221 (0.29)
1.134 (0.861–1.494)
0.411
VDR rs2228570
= 162
= 371
CC
43 (0.27)
103 (0.28)
Referent
0.386
CT
93 (0.57)
183 (0.49)
1.217 (0.788–1.880)
0.384
TT
26 (0.16)
85 (0.23)
0.733 (0.416–1.290)
0.321
CT + TT
119 (0.73)
268 (0.72)
1.064 (0.702–1.613)
0.833
MAF
145 (0.45)
353 (0.48)
0.893 (0.687–1.160)
0.434
VDR rs1544410
= 170
= 372
GG
65 (0.38)
148 (0.40)
Referent
0.880
AG
79 (0.46)
165 (0.44)
1.090 (0.734–1.620)
0.687
AA
26 (0.15)
59 (0.16)
1.003 (0.581–1.732)
1.000
AG + AA
105 (0.62)
224 (0.60)
1.067 (0.735–1.549)
0.776
MAF
131 (0.39)
283 (0.38)
1.021 (0.784–1.329)
0.931
RXRA rs10776909
= 172
= 378
CC
112 (0.65)
250 (0.66)
Referent
0.483
CT
48 (0.28)
112 (0.30)
0.957 (0.638–1.434)
0.838
TT
12 (0.07)
16 (0.04)
1.674 (0.767–3.656)
0.209
CT + TT
60 (0.35)
128 (0.34)
1.046 (0.716–1.529)
0.846
MAF
72 (0.21)
144 (0.19)
1.125 (0.819–1.545)
0.518
RXRA rs10881578
= 173
= 377
AA
89 (0.51)
183 (0.48)
Referent
0.682
AG
65 (0.38)
154 (0.41)
0.868 (0.591–1.275)
0.494
GG
19 (0.11)
40 (0.11)
0.977 (0.535–1.783)
1.000
AG + GG
84 (0.49)
194 (0.51)
0.890 (0.621–1.276)
0.582
MAF
103 (0.30)
234 (0.31)
0.942 (0.714–1.243)
0.725
RXRA rs749759
= 169
= 370
GG
100 (0.59)
221 (0.60)
Referent
0.924
AG
59 (0.35)
123 (0.33)
1.060 (0.718–1.566)
0.842
AA
10 (0.06)
26 (0.07)
0.850 (0.395–1.830)
0.710
AG + AA
69 (0.41)
149 (0.40)
1.023 (0.707–1.482)
0.925
MAF
79 (0.23)
175 (0.24)
0.985 (0.727–1.334)
0.983
CAD: coronary artery disease, DM: diabetes mellitus, and MAF: minor allele frequency.
