Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin

Figure 2

Blood glucose levels measured in oral glucose tolerance test (OGTT) experiments with (a) high fat diet and Streptozotocin induced (HFD/STZ) C57BL/6 and (b) db/db mice are plotted here. Left panels show the variation in the blood glucose value as a function of time, and the right panels have plots of g/g ratios for different treatments shown in left panels. The results are expressed as mean ± S.E.M. values are as mentioned in Methods (Section 2.8).

(a) HFD/STZ C57BL/6 ( per drug/protein/PBS)

(b) db/db ( per drug/protein/PBS)