Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis

Figure 5

LMWF reduced oxidative stress in diabetic GK rats. Administration with 50 and 100 mg/kg/day LMWF decreased MDA content (a) and increased SOD activity (b) in cardiac tissues of diabetic rats. (c) Administration with 100 mg/kg/day LMWF has no significant effect on the CAT activity of cardiac tissue in diabetic rats. versus control group, versus DM group. = 8–10 in each group. (d) Western blots were performed to determine the expression of PKCβ1, PKCβ2, and PKCα in cardiac tissues of each group. (e) The densitometry value of PKC was normalized to that of GAPDH and data are presented as the mean ± SEM. The statistical analysis was performed. versus control group, versus DM group. in each group.

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