Metformin Rescues the MG63 Osteoblasts against the Effect of High Glucose on Proliferation

Figure 2

Results of real-time PCR and Western blot. MMP1 (a), MMP2 (b), Col1α (c), OCN (d), OPG (e), RANKL (f) mRNA expression and protein of MG63 cells under control DMEM (ctrl), normal glucose (NG), high glucose (HG), and metformin treatment + high glucose (HG + Met). ^∗𝑃<0.05, HG + Met versus ctrl, NG (5.5 mmol/L), and HG (16.7 mmol/L); ^∗∗𝑃<0.05, HG + Met versus with HG (16.7 mmol/L); ^#𝑃<0.05, HG (16.7 mmol/L) versus ctrl and NG (5.5 mmol/L).

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