JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Reduces Food Preference for Fat
Figure 1
Effects of dietary fat on the suppression of food intake by JTT-130. Effect of JTT-130 on the suppression of food intake was assessed as described previously [15]. JTT-130 was administered orally to rats at a dosage of 10 mg/kg after 24 h food deprivation. Rats were allowed to have free access to 3.1% fat (a) or 35% fat (b) diets immediately after JTT-130 dosing. Cumulative food intake was monitored for up to 24 h after dosing JTT-130. Data are presented as means ± S.E. from six animals. versus control group.
