Decreased Neuronal Bursting and Phase Synchrony in the Hippocampus of Streptozotocin Diabetic Rats

Figure 4

Comparison of burst ratio and number of spikes within burst between groups. The burst ratio of neurons from diabetic rats (𝑛=26) is significantly lower than that of control rats (𝑛=59, 𝑃<0.001, Mann-Whitney test). Decrease of the number of spikes within bursts in diabetic rats was also observed (𝑃<0.001, Mann-Whitney test). Compared to that of diabetic rats, APP 17-mer peptide increased the burst ratio and number of spikes within bursts (𝑛=35, 𝑃<0.05 for burst ratio; 𝑃<0.001 for number of spikes within bursts, Mann-Whitney test) but still had significant difference with control rats (𝑃<0.01, Mann-Whitney test, for burst ratio; 𝑃<0.001 for number of spikes within bursts). “𝑛” represents number of neurons.

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