Decreased Neuronal Bursting and Phase Synchrony in the Hippocampus of Streptozotocin Diabetic Rats

Figure 5

Comparison of intraburst amplitude attenuation between the three groups. Amplitude attenuation within bursts was reduced in diabetic rats (𝑛=26) either for the 2nd/1st spike (𝑃<0.001, Mann-Whitney test) or for the 3rd/1st spike (𝑃<0.001, Mann-Whitney test). Treatment of APP 17-mer peptide partially reversed the decrease in amplitude attenuation (𝑛=35, 𝑃<0.001, Mann-Whitney test, for the second spike; 𝑃<0.001 for the third spike). The difference in amplitude attenuation between APP and Ctrl group (𝑛=59) only was significant at the third spike (𝑃<0.001, Mann-Whitney test). For the second spike, no difference was observed (𝑃=0.314, Mann-Whitney test). “𝑛” represents number of neurons.