Effect of Ranirestat, a New Aldose Reductase Inhibitor, on Diabetic Retinopathy in SDT Rats

Figure 3

HbA1c levels of the study animals. The mean HbA1c levels of the SD rats are significantly lower than those of the SDT rats with or without treatment. There is no significant difference in the HbA1c levels among the SDT rats with or without treatment. NDM: normal SD rats; DM: untreated SDT rats; rani (0.1): ranirestat-treated SDT rats (0.1 mg/kg/day); rani (1.0): ranirestat-treated SDT rats (1.0 mg/kg/day); rani (10): ranirestat-treated SDT rats (10 mg/kg/day); epa (100): epalrestat-treated SDT rats (100 mg/kg/day) [21].