Effect of Ranirestat, a New Aldose Reductase Inhibitor, on Diabetic Retinopathy in SDT Rats

Table 1

The mean retinal thickness and mean area of stained GFAP in each group. 31 wDM: 31-week-old SDT rats; 33 wNDM: 33-week-old normal SD rats; NDM: normal SD rats older than 50 weeks; DM: untreated SD rats older than 50 weeks; rani (0.1): ranirestat-treated SDT rats (0.1 mg/kg/day); rani (1.0): ranirestat-treated SDT rats (1.0 mg/kg/day); rani (10): ranirestat-treated SDT rats (10 mg/kg/day); epa (100): epalrestat-treated SDT rats (100 mg/kg/day).

	31 wDM	33 wNDM	NDM	DM	rani (0.1)	rani (1.0)	rani (10)	epa (100)
Mean retinal thickness (μm)
value	0.22; (compared with DM); 0.021; (compared with 33 wNDM)	0.023; (compared with NDM)	0.0076; (compared with DM)		0.017; (compared with DM)	0.0052; (compared with DM)	0.016; (compared with DM)	0.057; (compared with DM)
Mean area of stained; GFAP (µm^2)
value	0.0055; (compared with DM); 0.24; (compared with 33 wNDM)	0.0055; (compared with NDM)	0.0044; (compared with DM)		0.13; (compared with DM)	0.0052; (compared with DM)	0.028; (compared with DM)	0.11; (compared with DM)