The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

Table 1

Characteristics of all studies assessing the relationship between VEGF and diabetic retinopathy (DR versus DWR).

First author	Year	Country/racial decent	Study design	Cases^a (DR)	Controls^a (DWR)		Cases			Controls		HWE
						11^b	12^b	22^b	11^b	12^b	22^b	𝑋^2 control population
−634 G>C (rs2010963)
Awata [17]	2005	Japan (Asian)	Hospital based controls	175	203	46	91	38	75	95	30	0.99
Globočnik Petrovič [18]	2008	Slovene (Caucasian)	Hospital based controls	206	143	79	103	24	61	67	15	0.58
Uthra [19]	2008	India (Asian)	Population based controls	131	82	60	51	9	44	29	6	0.69
Nakamura [20]	2009	Japan (Asian)	Hospital based controls	177	292	63	79	34	84	146	59	0.75
Chun [21]	2010	Korea (Asian)	Hospital based controls	253	134	85	125	43	43	69	22	0.51
Yang [22]	2011	China (Asian)	Hospital based controls	129	139	36	74	19	39	72	26	0.47
Bleda [23]	2012	Spain (Caucasian)	Hospital based controls	14	26	7	5	2	10	11	5	0.53
–2578 C/A (rs699947)
Awata [17]	2005	Japan (Asian)	Hospital based controls	175	203	95	70	10	93	91	19	0.62
Abhary [24]	2009	Australia (Caucasian)	Hospital based controls	139	187	31	74	31	45	91	45	0.94
Nakamura [20]	2009	Japan (Asian)	Hospital based controls	177	292	85	70	22	163	107	22	0.44
Chun [21]	2010	Korea (Asian)	Hospital based controls	253	134	123	115	15	92	36	6	0.31
Yang [22]	2011	China (Asian)	Hospital based controls	129	139	66	47	16	82	51	5	0.38
Bleda [23]	2012	Spain (Caucasian)	Hospital based controls	14	26	0	12	2	8	10	8	0.23
+936 C/T (rs3025039)
Awata [25]	2002	Japan (Asian)	Hospital based controls	150	118	93	47	10	85	31	2	0.66
Uthra [19]	2008	India (Asian)	Population based controls	131	82	111	19	0	65	17	0	0.29
Kim [26]	2009	Korea (Asian)	Population based controls	121	277	55	63	3	226	51	0	0.09
Yang [22]	2011	China (Asian)	Hospital based controls	129	139	83	42	3	89	47	3	0.25
−460 T/C (rs833061)
Awata [25]	2002	Japan (Asian)	Hospital based controls	150	118	79	58	13	52	57	9	0.21
Suganthalakshmi [27]	2006	India (Asian)	Hospital based controls	120	90	36	81	3	61	29	0	0.06
Yang [22]	2011	China (Asian)	Hospital based controls	129	139	65	46	16	81	52	5	0.33

DR: diabetic retinopathy; DWR: diabetic without retinopathy; HWE: Hardy-Weinberg equilibrium.
^aSample size.
^b11: wild-type homozygote; 12: heterozygote; 22: variant homozygote.