The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

Table 2

Characteristics of all studies assessing the relationship between VEGF and diabetic retinopathy (PDR versus NPDR).

First author	Year	Country/racial decent	Study design	Cases^a (PDR)	Controls^a (NPDR)		Cases			Controls
						11^b	12^b	22^b	11^b	12^b	22^b
−634 G>C (rs2010963)
Awata [25]	2002	Japan (Asian)	Hospital based controls	70	80	24	30	16	14	51	15
Uthra [19]	2008	India (Asian)	Population based controls	44	87	21	17	3	39	33	7
Chun [21]	2010	Korea (Asian)	Hospital based controls	145	108	48	73	24	37	52	19
+936 C/T (rs3025039)
Awata [25]	2002	Japan (Asian)	Hospital based controls	70	80	44	20	6	49	27	4
Uthra [19]	2008	India (Asian)	Population based controls	44	87	35	9	0	76	10	0
Kim [26]	2009	Korea (Asian)	Population based controls	37	84	15	19	3	40	44	15

PDR: proliferative diabetic retinopathy; NPDR: nonproliferative diabetic retinopathy.
^aSample size.
^b11: wild-type homozygote; 12: heterozygote; 22: variant homozygote.