Review Article
Renal Protective Effect of Sirtuin 1
Table 1
Biological effects of SIRTs.
| Substrates | Biological effects |
| FOXO, p53 | Regulating cell cycle | Histones H1/H3/H4, Ku70 | Alleviating cell apoptosis | FOXO1, PGC-1α | Alleviating glucose metabolism, lipid metabolism, and insulin secretion | FOXO1 | Alleviating antioxidant | NF-κB | Alleviating inflammatory reaction |
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p53: protein 53; FOXO: forkhead-box transcription factor; PGC-1α: peroxisome proliferator-activated receptor-coactivator-1 α; NF-κB: nuclear factor-κB.
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