Urinary Methylmalonic Acid as an Indicator of Early Vitamin B12 Deficiency and Its Role in Polyneuropathy in Type 2 Diabetes

Table 2

Logistic analysis of influencing factors of diabetic polyneuropathy.

Parameters	OR value (95% CI)	P value
Age (year)	0.73 (0.84–1.08)	0.59
Duration (year)	1.543 (1.302–1.829)	0.045
Low-density lipoprotein cholesterol (mmol/L)	0.76 (0.63–0.89)	0.587
High-density lipoprotein cholesterol (mmol/L)	1.03 (0.81–1.42)	0.407
Triglycerides (mmol/L)	0.27 (0.11–0.36)	0.816
Serum creatinine (umol/L)	1.15 (0.79–1.54)	0.313
HbA1c (%)	1.19 (0.85–1.43)	0.254
Mean corpuscular volume (fL)	0.18 (0.11–0.25)	0.884
Hemoglobin (g/L)	0.99 (0.70–1.27)	0.458
Ferritin (ug/L)	1.08 (0.93–1.21)	0.340
Folic acid (ng/L)	0.92 (0.86–0.96)	0.532
Urinary methylmalonic acid/creatinine (mmol/mol)	4.07 (3.15–5.46)	0.001
Blood methylmalonic acid (pg/mL)	2.152 (1.799–2.42)	0.02
Vitamin B12	0.88 (0.794–0.997)	0.547
Holotranscobalamin (pmol/L)	3.89 (2.77–4.56)	0.003