Research Article
Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus
Table 1
Clinical characteristics of patients and controls.
| | Patient group ( = 88) | Control group ( = 33) | Mean ± s.d./, % | Mean ± s.d./, % |
| Age (years) | 60.03 | ±12.22 | 58.82 | ±10.80 | Gender | | | | | Male | 38 | 43.2% | 17 | 51.5% | Female | 50 | 56.8% | 16 | 48.5% | BMI (kg/m2) | 31.52 | ±5.80 | 26.87 | ±3.89*** | Waist circumference (cm) | 108.75 | ±14.07 | 94.36 | ±9.75*** | Systolic pressure (mmHg) | 130.51 | ±14.40 | 118.03 | ±8.00*** | Diastolic pressure (mmHg) | 81.25 | ±8.17 | 74.24 | ±7.82*** | BDNF (pg/mL) | 206.81 | ±107.32 | 130.84 | ±59.81*** | Fasting blood glucose (mg/dL) | 170.36 | ±91.21 | 85.33 | ±11.49*** | Fasting insulin (µU/mL) | 9.26 | ±4.92 | 5.48 | ±2.13*** | HOMA-IR | 3.73 | ±3.05 | 1.16 | ±0.48*** | HbA1c (%) | 8.30 | ±2.37 | 5.42 | ±0.52*** | Triglyceride (mg/dL) | 175.95 | ±108.67 | 156.30 | ±65.02 | Total cholesterol (mg/dL) | 212.21 | ±35.97 | 199.20 | ±52.50 | LDL (mg/dL) | 128.18 | ±32.17 | 115.52 | ±44.26 | HDL (mg/dL) | 47.01 | ±13.54 | 48.27 | ±13.20 | CRP (mg/L) | 7.84 | ±2.84 | 2.57 | ±1.07*** | ESR (mm/hr) | 26.09 | ±10.54 | 19.79 | ±5.58*** | White blood cell (×103/µL) | 7278.41 | ±2190.07 | 6624.24 | ±1683.38 | Ferritin (ng/mL) | 84.88 | ±38.69 | 44.52 | ±26.58 | Creatinine clearance (mL/min) | 91.74 | ±40.88 | 158.54 | ±83.23*** | Oral antidiabetic drug | 56 | 64% | 0 | 0% | Oral antidiabetic drug plus insulin | 16 | 18% | 0 | 0% | Insulin | 16 | 18% | 0 | 0% | Antihypertension | 54 | 61% | 0 | 0% | Antilipid | 26 | 30% | 0 | 0% | Smoking history | 31 | 35.2% | 0 | 0% |
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Student’s -test, Yates’ continuity correction test, and Mann-Whitney test. Statistical significance: *** < 0.001. BMI: body mass index, BDNF: brain-derived neurotrophic factor, HOMA-IR: homeostasis model assessment of insulin resistance, LDL: low-density lipoprotein, HDL: high-density lipoprotein, CRP: C-reactive protein, and ESR: erythrocyte sedimentation rate.
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