Association of the Genetic Polymorphisms in Transcription Factor 7-Like 2 and Peroxisome Proliferator-Activated Receptors-γ2 with Type 2 Diabetes Mellitus and Its Interaction with Obesity Status in Emirati Population

Table 4

Genotype and allele frequency distribution for TCF7L2 rs10885409 variant and the risk of type 2 diabetes in the Emirati population in various groups based on obesity status.

	Without consideration of BMI			Obese (BMI >30)			Nonobese (BMI <30)
	T2DM	Healthy	P	T2DM	Nondiabetics	P	T2DM	Nondiabetics	P
Genotypes
CC	89 (32.8%)	65 (30.2%)	0.557	42 (28.2%)	31 (35.2%)	0.3082	46 (41.1%)	30 (26.1%)	0.0176
CT + TT	182 (67.2%)	150 (69.8%)		107 (71.8%)	57 (64.8%)		66 (58.9%)	85 (73.9%)
Allele frequencies
C	0.55	0.52	0.399	0.52	0.56	0.342	0.61	0.51	0.0376
T	0.45	0.48		0.48	0.44		0.39	0.49