Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function during Development of Type 2 Diabetes Mellitus
Table 1
Clinical and biochemical characteristics of the study subjects.
Variables
Control subjects (n = 40)
People with prediabetes (n = 52)
People with diabetes (n = 66)
Age (years)
38.4 ± 7.6
38.9 ± 9.5
42.5 ± 8.4
Sex, male/female ()
18/22
24/28
31/35
BMI (kg/m2)
25.9 ± 6.2
27.2 ± 5.5
25.4 ± 4.6
SBP (mm Hg)
116.3 ± 8.5
118.1 ± 8.6
119.3 ± 8.3
DBP (mm Hg)
74.7 ± 8.4
76.1 ± 7.8
75.4 ± 8.2
Glucose, fasting (mmol/L)
4.7 ± 0.5
5.1 ± 0.6
9.7 ± 3.6a
Glucose, 2 hrs (mmol/L)
6.5 ± 0.9
8.2 ± 1.4
16.3 ± 5.6a
HbA1c (%)
5.0 ± 0.4
5.7 ± 0.5
8.1 ± 2.4a
HbA1c (mmol/mol)
30.9 ± 4.3
38.4 ± 5.4
65.5 ± 26.0a
Insulin (µU/mL)
9.3 (6.7–14.8)
11.5 (8.6–17.8)
9.4 (5.9–18.6)
HOMA-IR
2.0 (1.6–3.1)
2.6 (1.9–4.1)
4.1 (2.7–7.7)bc
HOMA-%B (%)
168 (95–313)
149 (109–230)
39 (19–89)a
Data are mean ± SD, number, and median (interquartile range). Log-transformed variables, values given are median (interquartile range). versus control subjects and people with prediabetes; versus control subjects; versus people with prediabetes. BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HOMA-IR, homeostasis model assessment of insulin resistance; HOMA-%B, homeostasis model assessment of beta cell function.
