Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function during Development of Type 2 Diabetes Mellitus

Table 2

Patient characteristics and associations of HOMA-IR and HOMA-%B with different variables in people with prediabetes and newly diagnosed type 2 diabetes.

	Characteristics PD + DM (n = 118)	HOMA-IR		HOMA-%B
		Univariate ()	Multivariate ()	Univariate ()	Multivariate
Age (years)	40.8 ± 9.0	0.06	—	−0.06	—
Sex, m/f ()	55/63	—	—	—	—
BMI (Kg/m^2)	26.17 ± 5.03	0.12	0.21^a	0.19	—
SBP (mm Hg)	118.8 ± 8.4	−0.03	—	−0.12	—
DBP (mm Hg)	75.7 ± 8.0	−0.09	—	−0.13	—
Glucose, 2 hrs (mmol/L)	12.8 ± 5.9	0.20^a	0.67^c	−0.70^c	−0.33^a
HbA1c (%)	6.9 ± 2.1	0.06	—	−0.72^c	−0.41^b
HOMA-IR	3.2 (2.3–5.3)	—	—	0.27^b	0.46^c
HOMA-%B	95 (33–163)	0.27^b	0.74^c	—	—
sRAGE (pg/mL)	646 (482–897)	0.04	—	0.08	—

Data are mean ± SD, number, and median (interquartile range). Values were not normally distributed and log-transformed for statistical analysis. , Pearson’s univariate correlation coefficient; , standardized coefficient as given by stepwise multivariate regression analysis. Dashes in the multivariate columns correspond to variables excluded from the model due to for -values. PD + DM, people with prediabetes and diabetes together; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; ; ; .