Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial

Table 3

Changes from baseline biomarkers of kidney injury.

Parameters	Sulodexide ()	Placebo ()	value
Baseline urine TGF-beta1 (pg/mg Cr)	14.85 ± 8.02	14.55 ± 10.86	0.920
Change at end point (pg/mg Cr)	2.17 ± 6.96	8.44 ± 9.21^a	0.020
Baseline UACR (µg/mg Cr)	7.44 ± 7.36	8.17 ± 8.21	0.766
Change at end point (µg/mg Cr)	13.89 ± 32.25	15.05 ± 30.09^a	0.907
Baseline serum creatinine (mg/dL)	1.00 ± 0.29	0.97 ± 0.25	0.728
Change at end point (mg/dL)	−0.01 ± 0.15	−0.06 ± 0.11	0.285
Baseline estimated GFR (mL/min/1.73 m^2)	77.89 ± 34.21	76.17 ± 24.04	0.855
Change at end point (mL/min/1.73 m^2)	4.2 ± 19.3	7.31 ± 14.2	0.565

Data are mean ± SD; week 14 values compared with baseline: .