Polymorphisms of GLP-1 Receptor Gene and Response to GLP-1 Analogue in Patients with Poorly Controlled Type 2 Diabetes

Table 1

Clinical variables of all participants with GLP-1 analogue.

Variable	Baseline	End of the study
	36
Age (years old)	52.8 ± 2.4
Sex (female %)	44
BMI (kg/m^2)	28.87 ± 0.83
DM duration (years)	11.6 ± 1.3
A1C (%)	10.5 ± 0.2
A1C (mmol/mol)	91.3 ± 2.5
Fasting C-peptide (ng/mL)	1.68 ± 0.26	1.88 ± 0.27	0.353
Fasting insulin (mU/L)	31.85 ± 9.33	31.52 ± 15.50	0.971
Mean glucose (mg/dL)	180.2 ± 5.4	147.9 ± 3.8	<0.00
SDPG (mg/dL)	65.1 ± 3.3	50.7 ± 3.0	<0.00
MAGE (mg/dL)	123.9 ± 6.5	98.8 ± 6.4	0.00
HOMA-IR	15.23 ± 4.32	11.88 ± 6.00	0.343
ISI	4.43 ± 1.03	5.03 ± 0.80	0.570

Data are expressed as mean ± standard error mean.
SDPG: standard deviation of plasma glucose.
MAGE: mean amplitude of glycemic excursions.
HOMA-IR: homeostasis model assessment-insulin resistance.
ISI: insulin sensitivity index.
< 0.01 by paired- test.