Polymorphisms of GLP-1 Receptor Gene and Response to GLP-1 Analogue in Patients with Poorly Controlled Type 2 Diabetes
Table 3
Quantitative trait loci analysis of GLP1R gene variations with clinical response to the GLP-1 analogue by multiple linear regression analyses using additive genetic models with or without adjustment of co-valuables, including age, sex, BMI, DM duration, and glycemic states at baseline.
Gene variants (genotypes)
Clinical variables
Without adjustment
With adjustment
Coefficient (95% CI)
Coefficient (95% CI)
rs3765467 (CC, CT, TT)
Mean glucose_baseline
−1.604 (−18.944, 15.737)
0.852
−0.161 (−19.825, 19.502)
0.987
Treatment
4.091 (−8.100, 16.282)
0.500
14.353 (4.202, 24.504)
0.007
Change
−5.695 (−21.292, 9.902)
0.463
−14.514 (−32.324, 3.295)
0.106
MAGE_baseline
−7.464 (−28.355, 13.427)
0.473
−8.870 (−31.366, 13.626)
0.427
Treatment
5.453 (−15.296, 26.202)
0.597
13.222 (−10.084, 36.528)
0.255
Change
−12.917 (−34.013, 8.179)
0.222
−22.092 (−46.635, 2.451)
0.076
SDPG_baseline
−5.421 (−16.067, 5.224)
0.308
−7.647 (−19.858, 4.564)
0.210
Treatment
6.073 (−3.538, 15.684)
0.208
10.588 (0.779, 20.398)
0.035
Change
−11.494 (−21.161, −1.828)
0.021
−18.236 (−29.143, −7.328)
0.002
rs761386 (CC, CT, TT)
Mean glucose_baseline
−9.257 (−27.350, 8.835)
0.306
−2.968 (−22.396, 16.460)
0.757
Treatment
−7.850 (−20.561, 4.861)
0.218
−1.868 (−13.249, 9.513)
0.739
Change
−1.407 (−18.054, 15.240)
0.865
−1.100 (−19.545, 17.346)
0.904
MAGE_baseline
0.828 (−21.470, 23.126)
0.940
7.109 (−15.240, 29.459)
0.520
Treatment
−6.806 (−28.748, 15.137)
0.533
−7.774 (−31.184, 15.635)
0.502
Change
7.634 (−15.061, 30.329)
0.499
14.884 (−10.156, 39.923)
0.234
SDPG_baseline
8.493 (−2.571, 19.557)
0.128
10.451 (−1.319, 22.222)
0.080
Treatment
−3.737 (−14.079, 6.605)
0.468
−3.083 (−13.510, 7.344)
0.550
Change
12.230 (1.998, 22.462)
0.021
13.534 (1.826, 25.243)
0.025
SDPG: standard deviation of plasma glucose. MAGE: mean amplitude of glycemic excursions. CI: confidence interval.
