Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice
Table 2
Body weight, blood glucose, and HbA1c levels.
Normal mice
Diabetic mice
Before transplantation
After transplantation
Before transplantation
After transplantation
Saline
ES-AB
Saline
ES-AB
HbA1c (%)
4.0 ± 0.1
4.1 ± 0.2
4.1 ± 0.2
7.3 ± 1.4**
7.7 ± 2.1##
7.7 ± 2.5##
Blood glucose (mmol/L)
9.1 ± 1.6
9.2 ± 1.6
9.1 ± 1.6
23.1 ± 2.8**
25.8 ± 8.0##
24.2 ± 9.0##
Body weight (g)
30.6 ± 2.7
31.3 ± 3.0
31.9 ± 3.7
26.1 ± 3.1**
25.3 ± 3.2##
27.6 ± 1.6##
Results are means ± SD. ES-AB: mice transplanted angioblast-like cells induced from embryonic stem cell. ** versus pretreatment normal mice. ## versus posttreatment normal mice.