Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat

Figure 3

Characterization of glucose tolerance and insulin sensitivity of the ZF strain. (a) Blood glucose levels and (b) plasma insulin levels during OGTT at 12 weeks of age. (c) Blood glucose levels during ITT at 12 weeks of age. (d) AUC data on insulin secretion during OGTT in the ZF and ZFDM strains. The data are expressed as mean ± SEM. Welch’s t-test was used for comparisons between fa/fa (red, ) and +/+ (blue, ) rats ((a), (b), and (c)) and between fa/fa rats in the both strains (-6) (d).

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