Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System

Figure 1

Immunohistological images of pancreas slides stained for ubiquitin in lean and obese humans and chow and high fat fed mice after 24 weeks. (a) Pancreases were obtained from human organ donors and then were embedded in paraffin and cut into 5 µm thick sections. Immunohistochemistry was then performed, staining for ubiquitin. (b) Pancreatic sections from mice fed chow or on high fat diet for 24 weeks were stained for ubiquitin. Red arrows indicate islets with higher levels of ubiquitinated protein ((a) and (b)).

(a)

(b)