Rat Models of Diet-Induced Obesity and High Fat/Low Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints

Table 3

Effect of reversal of high fat diet, enalapril, or menhaden oil in diet-induced obese or type 2 diabetic rats on motor and sensory nerve conduction velocity, thermal nociception, and intraepidermal nerve fiber density.

Condition	MNCV; (m/sec)	SNCV; (m/sec)	Thermal nociception; (sec)	Intraepidermal nerve fiber; (profiles/mm)
Control (12)	61.3 ± 1.3	21.0 ± 0.4	10.0 ± 0.6	15.1 ± 0.5
Obese (11)	60.4 ± 2.3	18.5 ± 0.4^a	15.5 ± 0.7^a	10.3 ± 0.7^a
Obese + normal diet (10)	58.1 ± 2.2	19.1 ± 0.5^a	13.4 ± 1.0	11.6 ± 1.0^a
Obese + enalapril (12)	60.2 ± 2.6	19.7 ± 0.3	11.9 ± 0.6^d	14.1 ± 0.7^d
Obese + menhaden oil (12)	64.3 ± 2.9	20.4 ± 0.3^d	11.3 ± 0.7^d	14.1 ± 0.4^d
Diabetic (10)	44.3 ± 1.6^a,d	17.3 ± 0.3^a	17.4 ± 1.0^a	10.7 ± 0.9^a
Diabetic + normal diet (10)	47.3 ± 1.4^a,b,d	18.6 ± 0.4^a	15.9 ± 0.9^a	12.8 ± 0.8
Diabetic + enalapril (11)	48.5 ± 1.8^a,b	19.0 ± 0.5	11.9 ± 0.8^c	14.1 ± 0.9^c
Diabetic + menhaden oil (11)	52.3 ± 1.6^b,c	20.0 ± 0.4^c	10.6 ± 0.6^c	14.6 ± 0.9^c

Data are presented as the mean ± S.E.M. compared to control; compared to obese matched condition; compared to diabetic; compared to obese. Parentheses indicate the number of experimental animals.