Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats

Figure 5

Delta cell versus beta cell counts and somatostatin pancreatic and serum levels plus PPY serum levels in Wistar and GK rats. (a) Cell counts from immunohistochemical PI sections of Wistar “W” ( samples) and GK rats “G” ( samples) as % fraction of beta plus delta cells for cells as specified at the age of 31 and 79 weeks (; ). (b) SST mRNA quantification as the relative SST/beta actin ratio in PI of Wistar (black bar) and GK rats (gray bars) indicates ~14-fold increase of SST mRNA. Five estimates () at weeks 6 and 35, 37, or 39 (). (c) SST and (d) PPY in serum collected from the tail vein of Wistar “W” (black bars) and Goto-Kakizaki “G” (gray bars) rats aged 41 and 52 weeks ( (); for Wistar SST otherwise ).

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