Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptozotocin-Induced Diabetic Rats

Figure 3

TGT attenuated diabetes-induced renal inflammation. (a) Immunostaining of TLR4, NF-κB, IL-1β, and MCP-1 was shown for different groups. (b) Representative western blotting analysis of TLR4, NF-κB, IL-1β, and MCP-1 was shown for different groups. (c–f) Densitometric results of TLR4, NF-κB, IL-1β, and MCP-1, as determined by western blot. (g–j) The mRNA expressions of TLR4, NF-κB, IL-1β, and MCP-1 were shown for different groups. NC: normal control; DM: diabetic rats without drug treatment; TL: low-dose TGT (1 mg/kg/day); TM: medium-dose TGT (3 mg/kg/day); TH: high-dose TGT (6 mg/kg/day). versus NC group, versus DM group, versus TL group, and versus TM group.

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