Journal of Diabetes Research / 2015 / Article / Tab 4 / Research Article
Mild Type 2 Diabetes Mellitus Reduces the Susceptibility of the Heart to Ischemia/Reperfusion Injury: Identification of Underlying Gene Expression Changes Table 4 Significant upregulated and downregulated genes in Goto-Kakizaki (GK) and control rats 24 h after sham operation or myocardial infarction. MI indicates myocardial infarction; W: Wistar.
Functional groups Genes GK + sham fold change versus W + sham Cardiac fibrosis Ctgf +3.707 0.001532 Hypertrophy Nppa +6.2756 0.016233 Inflammation Il1b −3.1518 0.011374 Inflammation Tnf −3.1183 0.016066 Inflammation Crp −2.0963 0.035534 Functional groups Genes GK + MI fold change versus GK + sham Diabetes Tnf +5.6225
0.035036 Diabetes Pygl +3.1994 0.020738 Oxidative stress Gstp1 −2.0236 0.021563 Cardiac fibrosis Ccl11 −2.9549 0.035774 Functional groups Genes GK + MI fold change versus W + MI Diabetes Gpd1 +6.641 0.001417 Diabetes Igfbp5 +5.8232 0.01159 Diabetes Ifng +2.9216 0.005641 Diabetes Irs1 +2.7073 0.028661 Diabetes Irs2 +2.5629 0.026471 Apoptosis Cidea +6.8588 0.020129 Antioxidant Sod3 +8.4477 0.017228 Antioxidant Cat +3.6086 0.013688 Antioxidant Gstk1 +2.9415 0.013792 Antioxidant Gpx3 +2.5874 0.005335 Antioxidant Gpx4 +2.2143 0.008235 Antioxidant Txnrd2 +2.4704 0.015564 Oxidative stress Acadsb +2.4938 0.008752 PI3K-AKT Pdk2 +4.0001 0.01737 PI3K-AKT Irs1 +2.7073 0.028661 PI3K-AKT Prkcz +2.4657 0.012351 PI3K-AKT Pdk1 +2.4067 0.039144 Cardiac fibrosis Mmp2 +4.4052 0.005183 Hypertrophy Myl2 +4.069 0.004222 Diabetes Hmox1 −3.3902 0.004516 Diabetes Pygl −3.0173 0.034296 Diabetes Enpp1 −2.4937 0.008265 Diabetes Tgfb1 −2.4518 0.001187 Diabetes Pik3cd −2.3951 0.005374 Apoptosis Tp53 −2.5259 0.011446 Apoptosis Casp3 −2.427 0.012582 Apoptosis Bax −2.1017 0.00374 PIK-AKT Rps6ka1 −3.4451 0.002956 PIK-AKT Pik3cg −2.9438 0.009444 PIK-AKT Btk −2.7497 0.035023 PIK-AKT Prkcb −2.1591 0.003529 Inflammation Tnf −4.427 0.003721 Cardiac fibrosis Grem1 −6.0096 0.040211 Cardiac fibrosis Ctgf −2.8267 0.039161 Hypertrophy Acta1 −2.485 0.001472 Functional groups Genes W + MI fold change versus W + sham Diabetes Pygl +6.0176 0.012007 Diabetes Pik3cd +3.6417 0.00072 Diabetes Trib3 +3.4219 0.021015 Diabetes Enpp1 +2.8888 0.000436 Diabetes Acly +2.1769 0.000508 Diabetes Ptpn1 +2.1691 0.005677 Apoptosis Casp3 +2.8879 0.002393 Apoptosis Bax +2.5914 0.001228 Apoptosis Cideb +2.3322 0.000832 Apoptosis Tp53 +2.0869 0.007736 Oxidative stress Gsr +2.0059 0.013533 Antioxidants Srxn1 +2.4303 0.002489 PIK-AKT Btk +5.0358 0.009847 PIK-AKT Rps6ka1 +4.6552 0.000443 PIK-AKT Pik3cg +2.9829 0.00643 PIK-AKT Hspb1 +2.2659 0.020669 PIK-AKT Prkcb +2.1022 0.005081 Inflammation Il6 +13.5898 0.009511 Inflammation Il1b +12.9385 0.027718 Inflammation Tnf +8.1656 0.000652 Inflammation Il10 +2.814 0.027362 Cardiac fibrosis Ctgf +11.9928 0.000743 Cardiac fibrosis Tgfb1 +3.647 0.000073 Hypertrophy Nppa +5.1685 0.02716 Hypertrophy Acta1 +3.5345 0.000146 Hypertrophy Fos +3.3651 0.043876 Ischemia/reperfusion injury Hmox1 +4.1327 0.004281 Diabetes Gpd1 −8.3354 0.000051 Diabetes Irs1 −4.025 0.008703 Diabetes Igfbp5 −3.7655 0.0052 Diabetes Ifng −3.2748 0.016763 Diabetes Gck −3.1419 0.046149 Diabetes Dpp4 −2.4258 0.019147 Apoptosis Cidea −6.5517 0.000294 Antioxidant Sod3 −14.7384 0.000054 Antioxidant Gstk1 −4.9174 0.000258 Antioxidant Txnrd2 −3.3769 0.000067 Antioxidant Gpx4 −3.1555 0.000135 Antioxidant Gpx3 −2.9402 0.005985 Antioxidant Sod1 −2.1671 0.000249 Antioxidant Sod2 −2.0326 0.002173 Oxidative stress Acadsb −4.092 0.002653 Antioxidant Cat −4.6839 0.000134 PI3K-AKT Pdk2 −6.0865 0.000008 PI3K-AKT Pdk1 −4.2831 0.000002 PI3K-AKT Pik3r1 −2.8108 0.009969 PI3K-AKT Grb10 −2.4946 0.000153 PI3K-AKT Prkcz −2.3207 0.039517 Cardiac fibrosis Mmp2 −5.9891 0.000011 Hypertrophy Myl2 −4.5332 0.000579
