Associations of Haplotypes Upstream of IRS1 with Insulin Resistance, Type 2 Diabetes, Dyslipidemia, Preclinical Atherosclerosis, and Skeletal Muscle LOC646736 mRNA Levels

Table 2

Haplotypes and associated risk for type 2 diabetes mellitus.

Haplotype	Frequencies (%)		Odds ratio (95% CI)
	Controls ()	Cases ()	Univariate analysis	Multivariate analysis^1
1111	0.164	0.164	0.90 (0.73–1.10)	0.89 (0.72–1.10)
1112	0.395	0.441	1.00	1.00
1121	0.030	0.032	0.94 (0.62–1.41)	0.90 (0.58–1.38)
1221	0.014	0.011	0.71 (0.37–1.37)	0.82 (0.42–1.61)
2112	0.029	0.026	0.80 (0.51–1.24)	0.82 (0.51–1.29)
2221	0.329	0.288	0.79 (0.67–0.93)^2	0.78 (0.66–0.92)^3

For haplotype designation, 1 or 2 refers to the major or minor alleles, respectively, in the following order: rs7578326, rs2943634, rs2943641, and rs2713538; global haplotype effects for univariate and multivariate analyses ; ¹adjusted for age, sex, and BMI; ²; ³.