Nuclear Factor of Activated T Cells Is Activated in the Endothelium of Retinal Microvessels in Diabetic Mice

Figure 7

In vivo inhibition of NFAT reduces diabetes-induced vascular permeability. Vascular permeability () in the retinas of 8-week-old Akita mice and WT mice that had been treated for 2 weeks with daily i.p. injections of A-285222 (0.29 mg/kg) or saline (control). , 10, 7, and 7 for WT, Akita, WT + A-285222, and Akita + A-285222, respectively. Two-way ANOVA with Bonferroni post hoc test revealed versus WT and ^## versus Akita.