Ileal Interposition in Rats with Experimental Type 2 Like Diabetes Improves Glycemic Control Independently of Glucose Absorption

Figure 1

Schematic drawing of the performed ileal interposition (IIP) surgery (a) and the experimental protocols (b). (a) Stomach and duodenum (DU) are indicated in white, jejunum (JE) is in light grey, and ileum (IL) is in dark grey. The unchanged anatomy after sham operation is shown on the left and the anatomy after IIP on the right. Regions that were analyzed for glucose uptake are cross-hatched. (b) The performed experimental procedures and measurements. Beginning with the 9th week of life, all animals were kept on high-fat diet (HFD). The number of employed animals is indicated in parenthesis. STZ, streptozotocin injection; GLP-1, measurements of GLP-1; UP, uptake measurements; IHC, immunohistochemistry and electron microscopy.

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