Ileal Interposition in Rats with Experimental Type 2 Like Diabetes Improves Glycemic Control Independently of Glucose Absorption

Figure 5

Effect of IIP on GLP-1 secretion after glucose gavage. In rats on HFD with STZ-induced diabetes either sham operation (white columns) or IIP surgery (grey columns) was performed during their 13th week of life. Four weeks later, the mice were force-fed with PBS (glucose bolus −) or with PBS containing glucose (glucose bolus +). Fifteen minutes later, total GLP-1 was measured in venous blood plasma obtained from the tail. Mean values ± SEM from six animals are presented. .